Is it possible to have exclusion zones when comparing the PDF files?

Using the plugin “Exclude areas from comparison” you can exclude defined areas from the comparison documents.
An area is defined by four number values: x, y, width, height - representing pixel coordinates. The values are relative to the pages as they would be displayed at 72 dpi. Multiple areas are supported as well as excluding an area from a specific page.

The plugin can be installed / activated in the plugin store of the i-net PDFC server / standalone application.